LongLabWeb photos

LongLabWeb

Here are more details and source info on the photos used in our welcoming page.

		Electron microscopy photo of E. coli bacteria [Source: www.nsf.gov webpage]. In a collaboration with Al Bennett (here at UCI), we have looked at the genomic changes associated with 2000 generations of E. coli evolving at different temperatures. We are continuing to look at genomic changes in other evolved lines, and are also looking at gene expression changes in these same lines.

		Volvox colonies [Source: Wim van Egmond's image gallery]. We don't work on Volvox (yet!), but they are extremely pretty and have many cool features!

		Drosophila melanogaster and its bristles [Sources: fly drawing from JT Patterson's 1943 publication, bristle image from Peter Lawrence's webpage]. We use bristle number in fruitflies as a model for understanding the genetic architecture of complex traits. We are currently looking for associations between this phenotype and DNA polymorphisms in cis-regulatory regions of genes in the Notch signaling pathway.

		Bicyclus anynana female showing the characteristic ventral eyespots along the wing margins [Image: courtesy of Paul M. Brakefield (University of Leiden, NL)]. We are using this system to study the genetic and developmental basis of ecologically-relevant morphological variation. We are currently carrying out an EST project and developing butterfly gene microarrays.

		Association between DNA polymorphisms in hairy and bristle number in Drosophila melanogaster [Source: Robin et al. 2002]. The genes of the neurogenic pathway involved in bristle development are good candidates for contributing to quantitative variation in bristle number in fruitflies. We are currently looking at variation in natural populations of D. melanogaster.

		Sequencing traces from ABI machine [Photo: Stuart & Patricia]. In the lab, we have sequenced different alleles of a number of candidate genes in order to find DNA polymorphisms that potentially contribute to trait variation. We have been looking at neurogenic genes and bristle number in fruitflies, and wing patterning genes and eyespot size in butterflies.

		Typing SNPs on glass slides [Image: Tomi Pastinen (Montreal Genome Center, CA)]. We have developed high-throughput genotyping methodologies in collaboration with Tomi Pastinen that allow us to genotype hundreds of SNPs in large panels of thousands of individuals. We can apply this technology to association studies, QTL mapping panels, and many other genotyping problems.

		LD pattern in the Drosophila Delta locus [Source: Genissel et al. 2004]. We are interested in using linkage disequilibrium (LD) mapping to dissect complex traits. We are characterizing patterns of LD in Drosophila melanogaster chromosomes, and using coalescent simulations to understand how we can apply LD mapping approaches to human populations.

	HOME
	PEOPLE
	RESEARCH
	PUBLICATIONS
	TEACHING
	TOOLS
	LINKS